Received error message 0xE8000001. Mac would not connect with iPhone. Possibly a USB hub is going bad, but several causes can be the root of the connection problem. My solution was to simply change to a different port on the hub.
See several other causes and solutions here ...
http://www.fixya.com/support/t777187-iphone_3g_error_0xe8000001
See also Google search ...
iPhone 0xE8000001
